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人才队伍 - 您当前所在位置: > 人才队伍 > 科研团队
电话:0731-84327621
联系人:邵女士
地址:湖南省长沙市湘雅路87号
邮编:410008
陈永恒教授
文章来源:本站 更新时间:2012/11/27 13:45:19

 

陈永恒, 1975年5月出生,2000年中南大学湘雅医学院临床医学七年制毕业,2006年获美国南加州大学病理学博士学位,2006-2014年在南加州大学从事博士后研究和助理教授工作。现任中南大学湘雅医院卫生部肿瘤蛋白质组学重点实验室教授,博士生导师。2014年湖南省“百人计划”引进人才,2015年中南大学“升华学者”特聘教授。担任湖南省肿瘤专业委员会副主任委员。
主要从事肿瘤、免疫性疾病和消化道疾病的分子机制和结构生物学研究,以及小分子抗癌药物的研发。主要研究方向包括:1,抑瘤基因TP53的结构生物学研究; 2,转录因子的结构生物学研究;3,酪氨酸激酶及小分子抑制剂的结构生物学研究;4,肿瘤的蛋白质组学研究及分子机制研究。先后在Journal of the American Chemical Society、Nucleic Acids Research、Cell Reports、Immunity、Structure等国际著名杂志上发表SCI论文30多 篇,;申报发明专利5项(两项国际专利),一项已获授权;主持国家自然科学基金面上项目2项,2014年获湖南省科技进步二等奖和湖南医学科技奖一等奖(均排名第三)。
主要代表性论文:
1.Ni F, Kung A, Duan Y, Shah V, Amador CD, Guo M, Fan X, Chen L, Chen Y*, McKenna CE*, Zhang C*. Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases. J Am Chem Soc. 2017 Jun 2. doi: 10.1021/jacs.7b03266.(通讯作者,影响因子:13.858)
2.Chen Y, Chen C, Zhang Z, Liu CC, Johnson ME, Espinoza CA, Edsall LE, Ren B, Zhou XJ, Grant SF, Wells AD, Chen L. (2015) DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Research.43(2):1268-82. (影响因子:10.162)
3.Chen Y, Zhang X, Dantas Machado AC, Ding Y, Chen Z, Qin PZ, Rohs R, Chen L. (2013) Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion. Nucleic Acids Research. 41(17):8368-76. (通讯作者,影响因子:10.162)
4.Chen YH, Yang CK, Xia M, Ou CY, Stallcup MR. (2007) Role of GAC63 in transcriptional activation mediated by -catenin. Nucleic Acid Research. 35 (6): 2084-92.(影响因子:10.162)
5.Zhefeng Xiao, Maoyu Li, Guoqing Li, Ying Fu, Fang Peng, Yongheng Chen*, Zhuchu Chen. Proteomic Characterization Reveals a Molecular Portrait of Nasopharyngeal Carcinoma Differentiation. Journal of Cancer.2016. 2017 Feb 11;8(4):570-577.(通讯作者)
6.Wu D, Guo M, Philips MA, Qu L, Jiang L, Li J, Chen X, Chen Z, Chen L, Chen Y*. Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455. PLoS One. 2016 Sep 12;11(9):e0162491. (通讯作者)
7.Wu D, Qu L, Fu Y, Li J, Jiang L, Chen X, Guo M, Chen Z, Chen L, Chen Y*. Expression and purification of the kinase domain of PINK1 in Pichia pastoris. Protein Expr Purif. 2016 Aug 18. pii: S1046-5928(16)30166-8. doi: 10.1016/j.pep.2016.08.010. [Epub ahead of print] PubMed PMID: 27546451. (通讯作者)
8.Li M, Peng F, Li G, Fu Y, Huang Y, Chen Z, Chen Y*. (2016) Proteomic analysis of stromal proteins in different stages of colorectal cancer establishes Tenascin-C as a stromal biomarker for colorectal cancer metastasis. Oncotarget. DOI: 10.18632/oncotarget.9362.(通讯作者)
9.Peng F, Huang Y, Li MY, Li GQ, Huang H, Guan R, Chen Z, Liang SP, Chen YH*. (2016) Dissecting characteristics and dynamics of differentially expressed proteins during multistage carcinogenesis of human colorectal cancer. World J Gastroenterology. 22(18):4515-28..(通讯作者)
10.Liu T, Wu HJ, Liang Y, Liang XJ, Huang HC, Zhao YZ, Liao QC, Chen YQ,Leng AM, Yuan WJ, Zhang GY, Peng J, Chen Y*. (2016) Tumor-Specific Expression of shVEGF and Suicide Gene as a Novel Strategy for Esophageal Cancer Therapy. World J Gastroenterology. In press.(通讯作者)
11.Duan Y, Chen L, Chen Y, Fan XG. (2014)c-Src binds to the cancer drug Ruxolitinib with an active conformation.PLoS One.9(9):e106225.(通讯作者)
12.Chen Y, Bates DL, Dey R, Chen PH, Machado AC, Laird-Offringa IA, Rohs R, Chen L. (2012) DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. Cell Reports. 29;2(5):1197-206. (第一作者)
13.Chen Y, Dey R, Chen L (2010). Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. Structure. 18(2): 246-56. (第一作者)
14.Chen YH, Beischlag TV, Kim JH, Perdew GH, Stallcup MR. (2006) Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. Journal of Biological Chemistry. 281(18):12242. (第一作者)
15.Chen YH, Kim JH, Stallcup MR. (2005) GAC63, a GRIP1-dependent nuclear receptor coactivator. Mol Cell Biol. 25(14): 5965. (第一作者)

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