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首页 > 研究生教育 > 博士生导师 博士生导师


陈永恒








陈永恒

2001-2006 年留学美国南加州大学,获病理学博士学位(导师:Michael R. Stallcup)。2007-2014 年在美国南加州大学先后任助理研究员、助理教授。2014年人才引进到中南大学湘雅医院卫健委肿瘤蛋白质组学重点实验室,任教授、博士生导师。2014年入选湖南省“百人计划”,2015 年获中南大学“升华学者”特聘教授, 2018年入选湖湘高层次人才聚集工程。现任湘雅医院抗癌药物国家联合地方工程实验室副主任。

长期从事分子生物学和结构生物学研究及蛋白结构基础上的新药研发,在转录因子和蛋白激酶的结构与功能方面有突出贡献,以第一作者/通讯作者在国际著名杂志Journal of the American Chemical SocietyIF14.357)、Nucleic Acids ResearchIF: 11.561,4 篇)、Cell ReportsIF: 8.032)等发表论文24 篇,授权国家发明专利3项,公示国家发明专利7 项。主持国家自然科学基金2项和湖南省重点科技计划项目2项,获湖南省科技进步二等奖1 项、湖南医学科技奖一等奖1项。任湖南省医学会肿瘤专业委员会副主任委员,任湖南省医学会常务理事。


Selected publications:

1.  Zhou Z, Chen X, Fu Y, Zhang Y, Dai S, Li J, Chen L, Xu G, Chen Z, Chen Y*. Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4. Chem Commun (Camb). 2019 May 1. doi: 10.1039/c9cc02052g.

2.  Chen X, Wei H, Li J, Liang X, Dai S, Jiang L, Guo M, Qu L, Chen Z, Chen L, Chen Y*. Structural basis for DNA recognition by FOXC2. Nucleic Acids Res. 2019 Feb 5. doi: 10.1093/nar/gkz077.

3.  Wu D, Guo M, Min X, Dai S, Li M, Tan S, Li G, Chen X, Ma Y, Li J, Jiang L, Qu L, Zhou Z, Chen Z, Chen L, Xu G, Chen Y*. LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance. Chem Commun (Camb). 2018 Oct 23;54(85):12089-12092.

4.  Ni F, Kung A, Duan Y, Shah V, Amador CD, Guo M, Fan X, Chen L, Chen Y*, McKenna CE*, Zhang C*. Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases. J Am Chem Soc. 2017 Jun 2. doi: 10.1021/jacs.7b03266.

5.  Chen Y, Chen C, Zhang Z, Liu CC, Johnson ME, Espinoza CA, Edsall LE, Ren B, Zhou XJ, Grant SF, Wells AD, Chen L. (2015) DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Research.43(2):1268-82

6.  Chen Y*, Zhang X, Dantas Machado AC, Ding Y, Chen Z, Qin PZ, Rohs R, Chen L. (2013) Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion. Nucleic Acids Res. 41(17):8368-76.

7.  Chen Y, Bates DL, Dey R, Chen PH, Machado AC, Laird-Offringa IA, Rohs R, Chen L. (2012) DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. Cell Reports. 29;2(5):1197-206.

8.  Chen Y, Dey R, Chen L (2010). Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer. Structure. 18(2): 246-56.

9.  Chen YH, Yang CK, Xia M, Ou CY, Stallcup MR. (2007) Role of GAC63 in transcriptional activation mediated by b-catenin. Nucleic Acid Research. 35 (6): 2084-92.

10.Chen YH, Beischlag TV, Kim JH, Perdew GH, Stallcup MR. (2006) Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. Journal of Biological Chemistry. 281(18):12242.

11.Chen YH, Kim JH, Stallcup MR. (2005) GAC63, a GRIP1-dependent nuclear receptor coactivator. Mol Cell Biol. 25(14): 5965.


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